Inactivated vaccine for horses against equine influenza and EHV.

Aqueous suspension for intramuscular injection.

Composition

Inactivated equine herpes virus type 1 (EHV1) and type 4 (EHV4) and inactivated influenza virus.  The vaccine contains aluminium hydroxide and Immunostim® to enhance the immunising effect. Sodium timerfonate is added as preservative. The vaccine may contain traces of antibiotics (neomycin, aureomycin), ovalbumin, and formaldehyde as remnants of the antigen production.

1 Dose (2 ml) contains:

inact. EHV1, strain RAC-H                                                                    at least 10^7.8  TCID₅₀

inact. EHV4, strain 2252                                                                       at least   10^6.5  TCID₅₀

inact. influenza virus, A/equi 1/Prague/1/56                                                     50 µg HA

inact. influenza virus, A/equi 2/Newmarket/1/93 (American-type)                       20 µg HA

inact. influenza virus, A/equi 2/Newmarket/2/93 (European-type)                       20 µg HA

Uses

For active immunisation of horses and ponies for reduction of respiratory disease caused by equine herpesvirus type 1 (EHV 1), equine herpesvirus type 4 (EHV 4) or equine influenza virus (EIV) of A/equi 1 and the current "American" and "European" strains of A/equi 2.

In the presence of field infections immunity against EHV-1 and EHV-4 is established within two weeks after the basic vaccination. Data from challenge experiments one month after primary vaccination show protective immunity. Within two weeks after the basic vaccination protective immunity against EIV is obtained. 

Revaccination at 6 months interval maintains the active immunity.

Dosage and administration

For horses : deep intramuscular injection of 2 ml into the neck or into the pectoral muscles.

Basic immunisation:

All horses not previously vaccinated should be vaccinated twice at an interval of about 6 weeks (V1-V2), followed by a third vaccination two to six months later (V 3). 

Foals should ideally be vaccinated at about six months of age. If vaccinating foals between 4 and 6 months of age, one should first test for the presence of maternally derived antibodies. Foals should not be vaccinated before 4 months of age.

Revaccination:

Every 6 months.

The vaccine syringe should be shaken well before use. Avoid the introduction of contamination during use. Use only sterile needles for administration.

Additional information

All in -contact horses should be vaccinated (herd immunity), to reduce pressure of infection within the population. Any new horse should have received at least the first two vaccinations of the basic vaccination scheme before introducing into or changing stables, and before attendance at shows, races etc. To optimise protection induced by the vaccine against EHV and EIV the following requirements must be met:

- Regular vaccinations of the entire herd.

- Avoid contact of unimmunised or sick horses with vaccinated groups.

Operator warning:

To the user:This product contains a very small amount of mineral oil.

Accidental/self injection of mineral oil-based compounds may result in severe pain and swelling and could result in the loss of the affected finger or thumb if prompt medical attention is not given. Ensure that the method of restraint, handling and administration, e.g. by the use of guarded needles, minimises the risk of accidental/self injection. If you are accidentally injected with this product, go AT ONCE to the nearest Accident and Emergency (Casualty) department of a hospital and show the information printed below to the Doctor (or nurse) on duty. Seek prompt medical advice even if only a very small amount is injected. If pain persists for more than 12 hours after medical examination, seek further medical advice.

To the Doctor: Even if very tiny amounts have been injected, accidental injection with oil-based products can cause intense swelling which may, for example, result in ischaemic necrosis and the loss of a digit. Expert, PROMPT, surgical attention is required and may necessitate early incision and irrigation of the injected area, especially where there is involvement of finger pulp or tendon.

Contra-indications, warnings, etc.

Avoid vaccination of sick horses, of horses that have intercurrent disease, heavy parasitic infestation or are in poor general condition, since in these cases no satisfactory immune response can be guaranteed.

Equilis Resequin is an adjuvanted vaccine and immunisation may occasionally result in temporary swellings at the injection site. Flat swellings up to 7 cm may occur. Larger swellings can be seen only on very rare occasions. Typically, these swellings do not cause any trouble and normally disappear within one to two weeks. An increase in body temperature of up to 1.5 °C may occasionally occur on the day after vaccination.

Occasional hypersensitivity reactions caused by egg-derived constituents in the vaccine may occur.

No information is available on the safety and efficacy from the concurrent use of this vaccine with any other. It is therefore recommended that no other vaccines should be administered within 14 days before or after vaccination with the product. 

Immunosuppressive drugs should generally not be used within14 days before or after vaccination, since they could prevent development of a satisfactory immune response.

The vaccine can be used during pregnancy and lactation.

Withdrawal period

Zero days.

FOR ANIMAL TREATMENT ONLY. KEEP OUT OF REACH AND SIGHT OF CHILDREN.

Pharmaceutical precautions

Store at between +2 and +8 °C, store out of light and do not freeze.

Any unused product or waste material should be disposed of in accordance with national requirements.

Legal category

POM-V                        To be supplied only on veterinary prescription.

Package quantities

Box with pre-filled syringes:       5 x 2 ml.

Further information

Nil.

Marketing Authorisation number

Vm 06376/4031        UK authorised veterinary medicinal product.

Marketing Authorisation holder

Intervet International B.V.

Represented in the UK by:

Intervet UK Ltd

Walton Manor

Walton

Milton Keynes

Bucks MK7 7AJ

Date of text preparation: 

04/07/06