Syringe containing a suspension of 500 mg cephapirin (as cephapirin benzathine) in an oily base.

Cephapirin, a first generation cephalosporin, is a broad spectrum antibiotic with bactericidal action against gram-positive and gram-negative bacteria.  Cephapirin is resistant to the action of penicillinase.

Metricure is indicated for the treatment of subacute and chronic endometritis in cows (at least 14 days after parturition) caused by bacteria sensitive to cephapirin.

The contents of one Metricure syringe should be introduced into the lumen of the uterus using the disposable catheter provided as follows:

1. Fix the syringe to the catheter.
2. Take the cervix of the uterus into one gloved hand introduced into the rectum
3. Introduce the catheter through the cervix into the lumen of the uterus, by gentle oscillating movements of the cervix.
4. Inject Metricure.

Depending on the response, a second treatment 7-14 days later may be required in some cases if clinical signs persist.

In animals that have been inseminated, Metricure may be used at one day after insemination.  In cases of pyometra, pre-treatment with prostaglandin is recommended in order to induce luteolysis and remove debris from the uterine cavity.

Not to be administered to animals known to be allergic to cephalosporins or penicillins.

The product is not indicated for use during pregnancy but can be used during lactation.

Not to be used concurrently with other intra-uterine antibiotic preparations.

Withdrawal periods

Meat - 48 hours after last treatment

Milk - Zero hours

Operator warnings

Penicillins and cephalosporins may cause sensitisation (allergy) following injection, inhalation, ingestion or skin contact.   Sensitivity to penicillin may lead to cross sensitivity to cephalosporins and vice versa.   Allergic reactions to these substances are occasionally serious.

1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended precautions.  Wear disposable polyethylene gloves.
3. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning.   Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention

FOR ANIMAL TREATMENT ONLY.  KEEP OUT OF REACH OF CHILDREN

Do not store above 25°C.   Syringes are for single use only.

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Packs containing 12 syringes.  Intra-uterine catheters are also provided for administration.

Nil