Nobilis IBmulti+ND+EDS Data Sheet

Presentation

Inactivated vaccine containing Massachusetts and D274 serotypes of Infectious Bronchitis virus (> 4.0 log₂ VN units each per dose), the Clone 30 strain of Newcastle Disease Virus (> 4.0 log₂ HI units) and Egg Drop Syndrome ‘76 virus (> 6.6 log₂ HI units), inactivated with formalin and suspended in the aqueous phase of an oil adjuvant emulsion containing liquid paraffin. 

Uses

For the vaccination of layer and breeder birds to: 

• Reduce clinical symptoms and egg production losses caused by infection with the Massachusetts serotype of IBV. 
  
  
• Reduce egg production losses and egg shell quality defects caused by infection with the D274 serotype of IBV. 
  
  
• Prevent mortality and clinical signs caused by Newcastle disease.
  
  
• Prevent egg production losses and egg quality defects caused by infection with Egg Drop Syndrome Virus. 

Active immunity develops within 4 weeks and lasts at least one laying period (for Infectious Bronchitis and Newcastle disease this requires birds to have been adequately primed with live vaccines during the growing phase). 

Dosage and administration

Each bird should be given 0.5 ml of vaccine intramuscularly in the breast or thigh muscle or subcutaneously into the back of the neck, using a medium-sized needle (20g  x ½"). 

Ensure that vaccination equipment is clean and sterile before use.  Do not use vaccination equipment with rubber parts as the excipient may attack certain types of rubber. 

Nobilis IBmulti+ND+EDS should be given to birds around 16-20 weeks of age but not less than 4 weeks before the expected onset of lay. 

Priming with live vaccines for Infectious Bronchitis and Newcastle Disease is necessary unless serological tests indicate otherwise.  The interval between priming and booster should not be less than 4 weeks and preferably more than 6 weeks. 

Contra-indications, warnings, etc

Only healthy birds should be vaccinated. Sick or weak birds will not develop adequate immunity following vaccination. 

Not to be used during lay or within 4 weeks before onset of lay. 

A slight swelling may be felt at the site of vaccination. 

Do not mix with other products. 

Operator warnings 

This product contains mineral oil.  Accidental/self injection may result in severe pain and swelling, particularly if injected into a joint or finger and in rare case could result in the loss of the affected finger if prompt medical attention is not given. 

If you are accidentally injected with this product, seek prompt medical advice even if only a very small amount is injected, and take the package insert with you. 

If pain persists for more than 12 hours after medical examination, seek medical advice again. 

To the physician 

This product contains mineral oil.  Even if small amounts have been injected, accidental injection with this oil-based product can cause intense swelling which may, for example, result in ischaemic necrosis and even the loss of a digit. Expert, PROMPT, surgical attention is required and may necessitate early incision and irrigation of the injected area, especially where there is involvement of finger pulp or tendon. 

Withdrawal period

Zero days. 

For animal treatment only. Keep out of reach of children. 

Pharmaceutical precautions

Store between +2° and +8°C.  Do not freeze.  Allow the vaccine to reach ambient temperature (15 - 25°C) before use.  The vaccine may occasionally separate into two layers on storage. This in no way affects its potency, but it should be shaken vigorously before and during use to ensure a good emulsification. 

Opened bottles should be used within 3 hours. 

Opened bottles containing unused vaccine should be disposed of in accordance with national requirements. 

Legal category

POM 

Package quantities

Bottles containing 500 ml (1000 doses). 

Further information

No information is available from the concurrent use of this vaccine with any other vaccines administered at the same time except for other Intervet inactivated vaccines containing the RT or Reo antigens given at the same time but at separate sites.  It is therefore recommended that no other vaccine should be administered within 14 days before or after vaccination with Nobilis IBmulti+ND+EDS. 

A good immune response is reliant on the reaction of an immunogenic agent and a fully competent immune system.  Immunogenicity of the vaccine antigen will be reduced by poor storage or inappropriate administration.  Immuno-competence of the animal may be compromised by a variety of factors including poor health, nutritional status, genetic factors, concurrent drug therapy and stress.  Under certain conditions, for example extreme disease pressure and variant challenge, fully immune birds may succumb to disease.  Therefore, successful vaccination may not be synonymous with full protection in the face of a disease challenge.

Marketing authorisation number

Vm 01708/4367