Nobilis Rhino CV Data Sheet

Lyophilisate for suspension for oculo/nasal or sprayapplication

Presentation

Liveattenuated vaccine containing per dose >10^1.5 TCID₅₀and <10^3.7 TCID₅₀ ofavian rhinotracheitis virus strain 11/94 sub-type B.   

Uses

The growth characteristic of the vaccine strain in Chicken Embryo Fibroblasts allows differentiation from field virus. Indicative results can be obtainedby specialised laboratories. 

For broilers, future layers and breeders from one day of age.

Broilers, future layers and breeders

Active immunisation in order to reduce the frequency and the severity of clinical signs due to infection with avian rhinotracheitis virus (avian metapneumovirus). The onset of immunity is 3 weeks and the duration of immunity is 16 weeks post-vaccination.

Future layers and breeders

Priming with Nobilis Rhino CV, followed by a second vaccination with an inactivated vaccine containing the avian rhinotracheitis virus strain But1#8544 before the onset of lay results in a reduction of the clinical signs including egg drop, caused by infection with avian rhinotracheitis virus. Protective immunity is maintained for the normal laying period.

Dosage and administration

Oculo/nasaladministration viaeye- or nose-drop method or viacoarse spray, one dose per bird from 1 day old.

Oculo/nasal route 

Reconstitute the freeze-dried vaccine in clean, disinfectant- and antiseptic-free water to which 2% liquid skimmed milk is added and administer by means of a standardised dropper. The amount of fluid required for eye- or nose-drop administration depends on the number of doses and the droplet size, but approximately 35 ml per 1000 doses is used. Apply one drop in a nose or eye. Check that the drop is entirely absorbed before releasing the bird.

Spray vaccination

The vaccine must be reconstituted with clean, disinfectant- and antiseptic-free water to which 2% of liquid skimmed milk is added. The appropriate number of vials must be opened under water. The volume of vaccine suspension must be sufficient to ensure a homogeneous vaccination of the birds.

Depending on the age of the chickens to be vaccinated and the rearing system, take 250 to 500 ml of water per 1000 doses. The vaccine suspension is to be sprayed evenly over the appropriate number of animals at a distance of 30-40 cm with a regular spraying apparatus, preferably when the animals sit together under a dim light. The spray apparatus must be free from sediments, corrosion and traces of disinfectants and ideally should be used for vaccination purposes only.

If applicable, reduce ventilation to prevent loss of spray.

Contra-indications, warnings, etc.

In a low percentage of flocks (less than 10 %), vaccination can lead to slight nasal discharge or coughing by some birds between 2 to 7 days after administration for 1 to 2 days.

Only vaccinate healthy birds.

In order to reduce the circulation of the vaccine strain, all susceptible animals on the site have to be vaccinated properly and preferably at the same time. The vaccine virus can spread to other susceptible species with which they have direct contact. It was shown that the spreading has negligible impact on turkeys, which together with chickens constitute the species that are most susceptible to avian rhinotracheitis virus.

Do not use in birds in lay and/or within 4 weeks before the onset of the laying period.

No information is available on the safety and efficacy from the use of this vaccine together with any other within common vaccination programmes except the following live Intervet vaccines when administered at the same day:vaccines against infectious bronchitis containing strain H120 and against Newcastle disease containing strains Clone 30 or C2and infectious bronchitis  vaccine (strain IB Ma 5) when given on day 1 (the efficacy of the IB Ma5 vaccine has not been investigated). 

Intervet’s live vaccine against Gumboro disease (infectious bursal disease) containing the D78 strain can be given 7 days after Nobilis Rhino CV.

It is recommended that no other vaccines should be administered within 14 days before or after vaccination with the product.  Do not use with any other vaccine or immunological product except those mentioned above.

Withdrawal period:     

Zero days.

FOR ANIMAL TREATMENT ONLY. KEEP OUT OF REACH OF CHILDREN.

Pharmaceutical precautions

Store in a refrigerator (+2°C to +8°C). Keep the container in the outer carton.

In use shelf life: 2 hours following reconstitution.

Disposal advice

Dispose of waste material by boiling, incineration or immersion in an appropriate disinfectant in accordance with national requirements.

Legal Category 

POM 

Package quantities

Carton containing 1, 2, 5, 10, 20 or 50 vials (Ph.Eur. type I) of 250, 500, 1000, 2500, 5,000, 10,000 or 25,000 doses closed with a halogenated rubber stopper and sealed with a colour coded aluminium cap. Not all pack sizes may be marketed.

Further information

Nil

Marketing Authorisation number

Vm01708/4505 

Marketing Authorisation holder

Intervet UK Ltd

Walton Manor

Walton

Milton Keynes 

MK7 7AJ

Date of text preparation                 

23 March 2005 

000525/JUL05/CUL/2k