Nobilis Salenvac T Data Sheet

An opaque aqueous vaccine suspension containing inactivated cells of Salmonella enteritidis phage type 4 and Salmonella typhimurium DT104. The vaccine contains aluminium hydroxide as an adjuvant and thiomersal as a preservative.

For the active immunisation of chickens to reduce caecum colonisation and faecal excretion with S. enteritidis and S. typhimurium.

Onset of immunity:4 weeks after the second administration.

Duration of immunity: until approximately 56-60 weeks of age for chickens vaccinated at 12 and 16 weeks.

Minor indication

In exceptional circumstances chickens from one day of age may be vaccinated in order to protect them in an environment where they are likely to become infected at an early stage in the rearing phase (epidemiologically indicated by recent outbreak of Salmonella or high infection pressure on the site).

Onset of immunity:4 weeks after the second administration.

Standard vaccination

Intramuscular injection of one dose of 0.5 ml.

Two vaccinations, with an interval of four weeks should be given. The recommended age for vaccination is 12 and 16 weeks of age. 

Emergency vaccination (when epidemiologically indicated in high-risk environments)

Intramuscular injection of one dose of 0.1 ml in one-day-old chicks.

After an interval of 4 weeks a repeat vaccination with a dose of 0.5 ml should be given.

It is recommended that an automatic vaccinator is used. Since the bottle containing this product is non-collapsible a vaccinator with a vented draw-off spike or similar device must be used. The instructions supplied with such syringes should be noted and care should be taken to ensure delivery of the full dose, particularly with the final doses from the bottle.

Do not use in birds in lay.

The vaccine contains an adjuvant and, as with most adjuvanted vaccines, immunisation may result in temporary swellings at the injection site.

In chickens of 4 weeks of age and above (receiving a dose of 0.5 ml), vaccination may rarely result in transient small palpable nodules at the injection site (reaching a maximum size of 1 cm²), evident immediately after vaccination and generally lasting only 1-2 days. Histopathological examination of injection sites 2 and 3 weeks after the administration of a single dose revealed that vaccination is associated with an intramuscular inflammatory response involving infiltration of macrophages and plasma cells.

Vaccination may also be associated with transient dullness, lethargy and lameness, lasting up to 2 days.

In one-day-old chicks (receiving 0.1 ml) the reactions are more noticeable.

It should be taken into account that post-vaccination injection site swellings are generally more evident than when administering 0.5 ml to birds of 4 weeks of age or older, and occasionally, the whole thigh may become swollen. These reactions are temporary and in the majority of cases resolved by 7 days. Exceptionally, a swelling may still be detectable 15 days after inoculation. In addition, after vaccination a significant proportion of the birds may show signs of lethargy, dullness and lameness, and a reduction of weight gain. 

Hygiene measures and good husbandry practices should also play an important part of a control programme to reduce the incidence of salmonella infection.

No studies have been performed to evaluate the effect of maternally derived antibodies on the response to vaccination. Therefore, for use in 1 day old chicks, where epidemiologically indicated, only birds from non-vaccinated and non-infected parent flocks should be vaccinated with Nobilis Salenvac T.

Vaccination causes a serological response in the chickens which may interfere with a surveillance programme based solely on serological screening without confirmatory bacteriology. The vaccine should therefore not be used when serological detection alone is used to assess flocks for infection with S. enteritidis and/or S. typhimurium. Vaccination also may cause cross reactions in the plate agglutination test for S. pullorum/gallinarum. Specific serological methods or bacteriology should be used for the differential diagnosis.

No information is available on the safety and efficacy from the concurrent use of this vaccine with any other. It is therefore recommended that no other vaccines should be administered within 14 days before or after vaccination with the product.

Do not mix with any other vaccine/immunological product.

User safety

In the case of accidental self-injection, seek medical advice immediately and show the package insert or the label to the physician.

Withdrawal period

Zero days.

For animal treatment only.  Keep out of reach of children.

The vaccine bottle must be shaken before use.

Store at +2°C to +8°C.  Protect from freezing.  Use before the expiry date printed on the pack.

Use broached containers immediately. Partly used and empty packs, syringes and needles must be disposed of in accordance with local requirements.

500ml polyethylene multidose bottles.

Nil.