Presentation

Inactivated vaccine containing >2 I.U. Rabies virus strain Pasteur RIV per dose.   Also contains Aluminium phosphate as an adjuvant.   0.1 mg/ml Thiomersal are added as a preservative.

Uses 

For the active immunisation against rabies to reduce clinical signs and mortality.

Onset of immunity: an adequate serological response (>0.5 I.U.) has been demonstrated 2 to 3 weeks after vaccination. 

Duration of immunity: 3 years.

Dosage and administration

A single dose inoculation of 1 ml is sufficient irrespective of size, species or breed of animal. Sterile equipment should be used for administration. Avoid contamination of vaccine with traces of chemical sterilising agents.   Do not use chemicals such as disinfectant or spirit to disinfect the skin prior to inoculation.

Primary course and booster vaccination:

Dogs & cats

Primary vaccination age*           3 months or older

Booster vaccination                   every 3 years

Route of administration  intramuscularly or subcutaneously

* Primary vaccination may be administered at an earlier age (minimum in dogs and cats of 4 weeks of age), but then a repeat vaccination must be given at the age of 3 months.

Can be used during pregnancy in dogs.

Further information:

Limited safety data for ferrets are available from monitoring post vaccination reactions. Ferrets can be vaccinated subcutaneously from 3 months of age. An adequate serological response (>0.5 I.U.) has been demonstrated 1 month after vaccination and they should receive a booster vaccination every 18 months. 

Health regulations and requirements in certain countries specify that dogs must be revaccinated annually against rabies.

Pet Travel Scheme (PETS):

Animals intended for vaccination under the Pet Travel Scheme (PETS) must be identified by a permanent numbered microchip. This microchip number must be recorded on the record of the dog, cat and ferret vaccination at the time of rabies vaccination.

Experience has shown that a proportion of vaccinated animals, while protected, may not show the 0.5 I.U. antibody titre on blood testing required by the PETS scheme. Veterinary surgeons may wish to consider two vaccinations, particularly in young, naive animals. Blood sampling for antibody titres should ideally be carried out three weeks after the last vaccine injection.

Contra-indications, warnings, etc.

Only healthy animals should be vaccinated.   The vaccine may not be effective in animals incubating the disease at the time of vaccination.

A good immune response is reliant on the reaction of an immunogenic agent and a fully competent immune system.   Immunogenicity of the vaccine antigen will be reduced by poor storage or inappropriate administration.   Immunocompetence of the animal may be compromised by a variety of factors including poor health, nutritional status, genetic factors, concurrent drug therapy and stress. 

Some animals may be immunologically incompetent and fail to respond to vaccination. 

Animals that have received the corresponding anti-serum or immunosuppressive drugs should not be vaccinated until an interval of at least 4 weeks has elapsed.

Transient local reactions such as non-painful diffuse to firm swellings of approximately 1 cm in diameter may be observed for up to 3 weeks after subcutaneous vaccination.

In the rare event of a hypersensitivity reaction following vaccination, administer an antihistamine, corticosteroid or adrenaline, without delay and by the most immediate route.

After administration of an overdose no effects other than those described above occurred.

The presence of maternal antibodies can interfere with the response to vaccination.

Can be used during pregnancy in dogs. There are no laboratory data on use during pregnancy in other species, but on the basis of field experience, such use is expected to be safe.

No information is available on the safety and efficacy from the concurrent use of this vaccine with any other except Intervet vaccines of the Nobivac range containing one or more of the following: live canine distemper, canine adenovirus, canine parvovirus and canine parainfluenza and inactivated canine leptospirosis antigens or live feline viral rhinotracheitis virus, feline calicivirus and feline panleucopenia virus.   It is therefore recommended that no other vaccines than these should be administered within 14 days before or after vaccination with Nobivac Rabies.

Do not mix with any other vaccine/immunological products.

Withdrawal period:

Not applicable.

FOR ANIMAL TREATMENT ONLY.   KEEP OUT OF REACH AND SIGHT OF CHILDREN.

Pharmaceutical precautions

Store between +2°C and +8°C.   Do not freeze. 

Disposal advice:

Any unused veterinary medicinal product or waste material derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Legal category

POM-V                        To be supplied only on veterinary prescription.

Package quantities

Carton with 1, 10 or 50 glass type I vials with 1 ml and carton with 1 vial of type I with 10 ml with a rubber stopper and aluminium cap.   Not all presentations may be marketed.

Further information
Nil.

Marketing Authorisation number

Vm 01708/4325                       UK authorised veterinary medicinal product.

Marketing Authorisation holder

Intervet UK Ltd.

Walton Manor

Walton

Milton Keynes

Bucks, MK7 7AJ

Distributed in Northern Ireland by:

Intervet Ireland Ltd.

Magna Drive

Magna Business Park

Citywest Road

Dublin 24

Date of text preparation

17/05/06