Presentation 
A premix for medicated feed. 1 g Panacur 4% Powder contains 0.04 g active ingredient Fenbendazole Ph.Eur.

Uses 
Pigs: A broad spectrum anthelmintic for the treatment of pigs infected with immature and mature forms of gastro-intestinal and respiratory nematodes including:
Hyostrongylus rubidus     (red stomach worm)
Oesophagostomum spp.  (nodular worm)
Ascaris suum                  (round worm)
Trichuris suis                  (whipworm)
Metastrongylus apri         (lungworm) (as an aid in its control).

Cattle: For the treatment of cattle infected with mature and developing immature forms of nematodes of the gastro-intestinal and respiratory tracts including:
Ostertagia spp.               Haemonchus spp.
Cooperia spp.                 Oesophagostomum spp.
Trichostrongylus spp.      Strongyloides spp.
Bunostomum spp.           Trichuris spp.
Nematodirus spp.            Dictyocaulus viviparus
Panacur is usually effective against inhibited larvae of Ostertagia spp. and against Moniezia spp. of tapeworm.

Panacur has an ovicidal effect on nematode eggs.

Dosage and Administration:  
When incorporating at a rate of below 2 kg/tonne of final feed, the product must only be mixed by a manufacturer who is approved to mix at that level.

No dietary control is required before or after treatment.

Pigs: Panacur 4% Powder is suitable for herd medication.  The standard dose rate is 5 mg fenbendazole/kg bodyweight.  Assess bodyweight accurately before calculating.

Routine treatment – herd medication: Panacur 4% Powder may be administered to pigs either as a single dose or by divided dosage over 7 days. It may also be administered to sows over a period of 14 days. All methods of treatment are equally effective. To avoid underdosing, all incorporation rate calculations should be based on the heaviest pig in the group.
 
a) Single dose treatment:
Use the following formula to calculate how much Panacur 4% powder to add per tonne of feed:
dose = weight ÷ (intake × 8)  
where
dose = kg Panacur 4% Powder per tonne
weight = bodyweight in kg
intake = daily feed intake in kg

b) 7 day treatment:
The standard dose rate can be divided and administered in feed over 7 days. Use the following formula to calculate how much Panacur 4% Powder to add per tonne of feed:
dose = weight ÷ (intake × 56) 
where
dose = kg Panacur 4% Powder per tonne
weight = bodyweight in kg
intake = daily feed intake in kg
A suitably approved manufacturer must be responsible for mixing at these incorporation rates.

c) 14 day treatment of sows:
The standard dosage (5 mg fenbendazole/kg bodyweight) can be divided and administered in sows in the feed over 14 days. Use the following formula to calculate how much Panacur 4% Powder to add per tonne of feed:
dose = weight ÷ (intake × 112)
where
dose = kg Panacur 4% Powder per tonne
weight = bodyweight in kg
intake = daily feed intake in kg
A suitably approved manufacturer must be responsible for mixing at these incorporation rates.

Routine treatment – individual medication: Panacur 4% Powder may be administered to individual pigs, added to the feed. The measure provided with the pack delivers approximately 9.375 g Panacur 4% Powder. One measure is sufficient to treat a pig of 75 kg bodyweight. Two measures should be sufficient to treat a sow of 150 kg bodyweight, three measures for a sow of 225 kg bodyweight etc.

Treatment for specific infections: For the control of Metastrongylus apri (lungworm) and /or Trichuris suis, it is recommended that the dosage is divided and administered over 7 days for most effective treatment.

Suggested dosing programme for pigs: Sows and boars – Treat sows before entering farrowing accommodation and again after weaning. This will maintain the sow’s condition and reduce the risk of infestation to her piglets.
Boars should be treated every six months. 

Growing and finishing pigs: Dose weaners or growing pigs on purchase or on movement to finishing house. Where there is a high risk of Ascariasis (“Milk Spot Liver”), repeat treatment at monthly intervals.

Whole herd treatment: Treatment of the whole herd (all adult and young stock) simultaneously every 6 months will minimise the risk of re-infestation. 
This should be carried out routinely unless recommended otherwise by a veterinary surgeon. It should also be combined with careful attention to environmental hygiene which is especially important for control of “Milk Spot Liver”.

Outdoor pigs: When clean grazing is available, dose before moving stock onto it. If clean land is not available then pigs should be treated monthly from July to October.

Cattle:  9.375 g Panacur 4% Powder per 50 kg bodyweight on a single occasion, added to the feed.
           (= 7.5 mg fenbendazole/kg bodyweight)
(The scoop provided with the pack delivers approximately 9.375 g amounts of Panacur 4% Powder).

Alternatively, cattle can be treated by dividing the dose over 5 or 10 consecutive days.

a)             5 day treatment:

Administer a daily dose of 1.5 mg fenbendazole per kg bodyweight for 5 consecutive days. This is most easily achieved by mixing 18.75 g Panacur 4% Powder with 5 kg feed, and feeding 1 kg medicated feed per 100 kg bodyweight daily for 5 days.

Practical dosage recommendations:

b)             10 day treatment:

Administer a daily dose of 0.75 mg fenbendazole per kg bodyweight for 10 consecutive days. This is most easily achieved by mixing 18.75 g Panacur 4% Powder into 10 kg feed and feeding 1 kg medicated feed per 100 kg bodyweight daily for 10 days.

Practical dosage recommendations:

Contra-indications, warnings, etc.

The product may not be effective against Trichuris and Strongyloides species when given by divided dosage in cattle.

Withdrawal periods:   

Animals must not be slaughtered for human consumption during treatment.

Pigs:      Meat –    3 days

Cattle:   Meat –   14 days

             Milk – 120 hours

FOR ANIMAL TREATMENT ONLY.  KEEP OUT OF REACH AND SIGHT OF CHILDREN.

Operator warnings:    

Incorporation into the feed must be done by a suitably approved manufacturer.   Impervious gloves must be worn when handling this product or feed containing this product.

When handling or mixing, care should be taken to avoid direct contact with the skin and inhalation of any dust by wearing protective clothing, rubber gloves and a non-disposable half-mask respirator conforming to European Standard EN149 or a non-disposable respirator to European Standard EN 140 with a filter to EN 143.

Wash hands after handling medicated feedstuffs.

Pharmaceutical precautions  

When preparing medicated feeds for pigs or cattle, which are to be administered over a number of days, to ensure thorough dispersion a pre-mix should be prepared first. For example, for pig feeds the Panacur 4% Powder should first be mixed with 2.5 kg feed for every tonne of medicated feed being manufactured. Once mixed, this should then be incorporated with the remaining feed.

The product can be incorporated into pelleted feed preconditioned with steam at a temperature not greater than 75^oC. 

Do not add to liquid feeds or supplements.

The product will remain stable in the finished feed for 3 months.

When incorporated at a rate of below 2 kg/tonne of final feed, the product must only be mixed by a manufacturer who is approved to mix at that level.

Any unused product or waste material should be disposed of in accordance with any national requirements.   Dangerous to aquatic life.   Do not contaminate ponds, waterways or ditches with the product or used containers.

Legal Category

POM-VPS                   To be supplied only on veterinary prescription.

Package Quantities    

25 kg drums and 2.5 kg buckets.

Further information    

Nil.

Marketing Authorisation number

Vm 01708/4449            UK authorised veterinary medicinal product.

Marketing Authorisation holder

Intervet UK Ltd.

Walton Manor, Walton

Milton Keynes

Bucks. MK7 7AJ

Date of text preparation

May 2006.

75060/Jul2006             

Item code:033259