Presentation

A ready to use colourless, aqueous solution for parenteral administration, containing synthetic releasing hormone analogue for both the luteinising and follicle stimulating hormones (LH-RH, GnRH, LH/FSH-RH).  Each ml contains 0.004mg Buserelin (Pyr-His-Trp-Ser-Tyr-D-Ser(Bu^t)-Leu-Arg-Pro Ethylamide) and 10mg benzyl alcohol, Ph.Eur. as an anti-microbial preservative.

Buserelin is equivalent to the natural LH/FSH releasing hormone produced in the hypothalamus.  It causes simultaneous release of luteinising hormone (LH) and follicle stimulating hormone (FSH) from the pituitary.

Uses

For the treatment of infertility of ovarian origin and improvement of pregnancy rate in cows.

For the synchronisation of oestrus in dairy cows and for reducing the calving to conception interval in these cows when used in conjunction with a PGF 2_α analogue with luteolytic activity as part of a 10-day fixed time insemination regime.

To induce ovulation of a mature follicle and thereby to synchronise ovulation more closely with mating in mares.

For the improvement of conception rate and induction of ovulation in rabbits.

To facilitate stripping and reduce mortality due to egg binding in rainbow trout.

Dosage and Administration

Receptal is preferably given by intramuscular injection.  However, the intravenous or subcutaneous routes may also be used if desired.  Syringes and needles should be from gamma irradiated packs.

Cattle: 

For the treatment of cows with fertility disorders of ovarian origin.

Follicular cysts- with or without signs of nymphomania - 5.0ml.

In the treatment of follicular cysts in cattle, it is unnecessary to manually express the cysts. A corpus luteum will usually be clearly detectable on either the affected or the normal ovary within about 8 days after administration of Receptal.  At the same time luteinisation and disappearance of the cysts may occur.  The response to treatment should be checked after 10‑14 days.  If no corpus luteum is present, or if newly formed cysts are detected, treatment should be repeated.

Artificial insemination or service may take place during the first oestrus after treatment.  On average this occurs 20 days after injection of Receptal.

Acyclia (true anoestrus)- 5.0ml.

To determine that the cow is truly acyclic, two rectal examinations should be carried out with an 11-day interval between examinations.  Alternatively, two samples of milk should be taken for milk progesterone assay with an 11-day interval between samples.

Oestrus should occur 8 - 22 days after treatment.  If oestrus has not been observed by this stage, a further rectal examination should be carried out.  If there are no palpable structures on the ovaries, then treatment should be repeated.  If, however, a corpus luteum is palpated, then prostaglandin F_2αor one of its analogues should be administered, thus allowing the animal to return to oestrus 2 - 3 days later.

Delayed Ovulation- 2.5ml.

This condition may be treated at the time of artificial insemination or service, or up to 6 - 8 hours beforehand.  Ovulation is usually induced within 24 hours of treatment.

Improvement of pregnancy rate of cows- 2.5ml.

Receptal should be injected at the time of insemination or up to 8 hours beforehand.  This helps to ensure that ovulation occurs at the correct time after insemination.

Improvement of pregnancy rate may also be achieved by a single injection on day 11 or 12 after insemination by helping to prevent luteolysis and consequent embryo mortality.

Note:  The induction of ovulation is not possible in the presence of a functional corpus luteum.

For the synchronisation of oestrus in dairy cows.

Receptal can be used as part of a 10-day GnRH/prostaglandin/GnRH oestrus synchronisation and insemination regime to increase submission rates and significantly reduce the calving to conception interval.  The use of Receptal 7 days prior to prostaglandin increases the proportion of cows able to respond to the prostaglandin and co-ordinates a new follicular wave so more cows will ovulate within a shorter time after prostaglandin.  A second Receptal treatment after the prostaglandin further tightens synchrony of ovulation in relation to the service time.  The Intervet GnRH/prostaglandin/GnRH regime (Intercept™) for breeding dairy cows at a pre-planned time without the need for specific heat detection is summarised below:

Day 0                  Receptal (2.5 ml).

Day 7                  Prostaglandin (at luteolytic dose).

Day 9                  Receptal (2.5 ml)     54-56 hours post prostaglandin or at AI if sooner.

Day 10                AI 72 hours post prostaglandin or at observed heat if sooner.

Mares:
To induce ovulation of a mature follicle and thereby to synchronise ovulation more closely with mating -10ml.
Receptal should be administered on the first day on which the follicle has reached its maximum size, this being determined by previous clinical history and rectal examinations.

Receptal is best given approximately 6 hours prior to service.  This may be achieved by administering Receptal in the morning with service in the afternoon of the same day or, alternatively, with the injection given in the early afternoon and service in the evening.

The mare should be served again the next morning if she is still in oestrus.  If ovulation has not occurred within 24 hours after treatment, then the injection should be repeated.

Rabbits:

Induction of ovulation for post-partum insemination- 0.2ml

Administer 0.2ml subcutaneously, 24 hours after parturition.  Insemination should be carried out directly after administration.

Improvement of conception rate- 0.2ml

Inject 0.2ml Receptal at the time of insemination or mating.

Rainbow Trout:

To facilitate stripping in male and female fish in spawning condition, and to reduce mortality due to egg binding

Inject Receptal at a dose rate of 0.75 - 1ml per kg bodyweight (3 - 4 micrograms Buserelin/kg bodyweight) by intramuscular injection, 2cm above the lateral line posterior to the dorsal fin.  Stripping should be performed 2 - 3 days after treatment.

Contra-indications, warnings, etc.

Not to be used in trout intended for human consumption.

Pregnancy rates to first insemination after use of the ‘Intercept’ fixed time insemination programme in cows may be reduced by some 12% in herds with pregnancy rates to first service above 50% and in first parity animals (heifers).  Highest pregnancy rates are achieved by servicing cows between 61 to 70 days after calving.

For animal treatment only. Keep out of the reach of children.

Withdrawal periods:

Cattle, horses and rabbits: meat - 0 days

Cattle: milk – 0 days

Not to be used in trout intended for human consumption.

Pharmaceutical precautions 

Do not store above 25^oC.  Protect from light.

Observe aseptic precautions.

Following withdrawal of the first dose, use the product within 14 days. 

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Legal Category 

POM

Package quantities

10ml and 5 x 10ml multidose glass bottles.

Further information

When using the Intercept fixed time insemination regime, it is recommended that cows showing signs of oestrus after prostaglandin treatment should be inseminated when observed in oestrus rather than completing the synchronisation programme.

Trials have shown that for cows holding to their first service, use of a GnRH/prostaglandin/GnRH regime can improve the calving to conception interval by 11 days when compared to controls.  When including all services, the calving to conception interval was shown to be improved by 7 days.

Marketing Authorisation number 

Vm 01708/4438

Marketing Authorisation holder
Intervet UK Ltd.
Walton Manor, Walton,
Milton Keynes, Bucks.
MK7 7AJ

Distributed in Northern Ireland by:
Intervet Ireland Ltd
Magna Drive
Magna Business Park
Citywest Road
Dublin24

Date of text preparation

July 2005