Tryplase Capsules Data Sheet

Presentation 

Dark green, hard gelatin capsules containing pancreatic enzymes in powder form.   Each capsule contains Pancreatin Ph Eur with not less than the following activities:

Amylase    9,000   Ph Eur units

Lipase      12,600   Ph Eur units  

Protease       450   Ph Eur units 

Uses 

Tryplase contains the three major pancreatic enzymes responsible for digestion of fat, protein and starch in the small intestine.   The formulation is particularly suitable for replacement therapy or supplementation in the dog and cat.   It is indicated in the treatment of impaired digestion and diarrhoea caused by deficiencies of exocrine pancreatic secretion.

Administration may also be indicated in cases of non-specific diarrhoea where persistent hypermotility of the intestine prevents adequate utilisation of pancreatic enzymes.

Dosage and administration 

When an animal receives more than one meal daily, the dose should be divided appropriately between the feeds.   The dose should be adjusted to obtain faeces of normal consistency and will thus be variable.   The table provides general guidance:

Species                                      Dosage

Dogs:                                        The contents of 2-5 capsules per day, sprinkled on food. 

                                                (5 capsules are sufficient to digest the declared fat, protein and

                                                carbohydrate content of 1 lb (approx. 500 g) of dog food).

Cats:                                         The contents of 1-2 capsules per day, sprinkled on food. 

                                                (2 capsules are sufficient to digest the declared fat, protein and

                                                carbohydrate content of 1/2 lb (approx. 250 g) of cat food).

Do not administer whole capsules.

If signs of disease persist or appear consult your Veterinary Surgeon.

Contra-indications, warnings, etc. 

The correct dosage should be adjusted to suit the individual case.

Operator warning:

Sprinkle on the feed with care as the powder can be irritant to skin and mucous membranes.  

Wash hands after administration of capsules.

FOR ANIMAL TREATMENT ONLY.  KEEP OUT OF REACH AND SIGHT OF CHILDREN.

Pharmaceutical precautions 

Do not store above 25°C. Store in tightly closed original container and in a dry place. 

Protect from light.

Dispose of used packaging and remaining product in the household refuse.

Legal category  

AVM-GSL

Package quantities                                                                                                                        

Packs of 100 or 250 capsules.

Further information

After a course of treatment and when symptoms are controlled, it is advisable to reduce the dose gradually over a seven day period in order to ascertain either the degree of recovery or necessity for a permanent maintenance dose.   Where permanent therapy is required, dose levels should be reduced periodically to see whether pancreatic recovery has taken place.    However, more often the deficiency is progressive and patients should be re-examined at intervals to ensure stability.

Proper dietary control is also essential for the successful management of cases suffering from pancreatic insufficiency. Consult a veterinary surgeon for advice.

Each capsule contains:

Amylase   - sufficient to digest 40 g of dietary starch.

Lipase      - sufficient to digest 17 g of dietary fat.

Protease   - sufficient to digest 34 g of dietary protein.

In exocrine pancreatic insufficiency the addition of these extracts to the feed aids in proper digestion of fat, protein and starch.

Marketing Authorisation number 

Vm 01708/4319

Marketing Authorisationholder

Intervet UK Ltd.                

Walton

Milton Keynes  

MK7 7AJ

Date of text   preparation:

March 2006