Presentation 

Vivitonin 50 mg tablets are orange-yellow, film-coated tablets, quarter-scored on one side. Each tablet contains 50 mg of the xanthine derivative Propentofylline. 

Vivitonin 100 mg tablets are orange-yellow, oblong film-coated tablets, half-scored on one side. Each tablet contains 100 mg of the xanthine derivative Propentofylline. 

Uses 

For improvement in dullness, lethargy and overall demeanour in dogs. Vivitonin is particularly useful in older dogs, where it may increase willingness to exercise and exercise tolerance.

Propentofylline has been shown to increase blood flow, particularly of the heart and skeletal muscle. It also increases the blood flow of the brain and therefore its oxygen supply, without increasing the brain's glucose demand. 

It has a modest positive chronotropic effect and a marked positive ionotropic effect.   In addition, it has been shown to have an anti-arrhythmic effect in dogs with myocardial ischemia and a bronchodilator action equivalent to that of aminophylline.

Propentofylline inhibits platelet aggregation and improves the flow properties of erythrocytes. It has a direct effect on the heart and reduces peripheral vascular resistance thereby lowering cardiac load. 

Some symptoms or conditions related to impaired blood circulation where Vivitonin may be of benefit are:

• Dullness, lethargy and depressed demeanour
• Decreased willingness to exercise and exercise tolerance
• Arrhythmia due to myocardial ischemia
• Conditions requiring improved circulation in the heart, brain and skeletal muscle 

Dosage and administration 

Vivitonin 50 mg tablets

One   tablet per 10 kg bodyweight twice a day. The tablets may be halved.

Dogs of less than 5 kg may receive a quarter tablet twice a day. 

Dogs of 20 kg or more can be given Vivitonin 100 mg tablets.

Vivitonin 100 mg tablets
One tablet per 20 kg bodyweight twice a day. 
Vivitonin 100 mg tablets may be halved but should not be quartered. 
For larger dogs more accurate dosing may be achieved using a combination of Vivitonin 100 mg and Vivitonin 50 mg tablets. 
Dogs of less than 20 kg can be given Vivitonin 50 mg tablets.

The tablets can be administered directly onto the back of the dog's tongue or can be mixed in a small ball of food and should be administered at least 30 minutes before feeding. 

Contra-indications, warnings, etc.

Do not administer to pregnant bitches or breeding animals, as it has not yet been evaluated in this class of animal. 

Specific diseases (e.g. kidney disease) should receive appropriate treatment. 

Consideration should be given to rationalising the medication of dogs already receiving treatment for congestive heart failure or bronchial disease.

Operator warnings:

Care should be taken to avoid accidental ingestion.

Wash hands after use.

For animal treatment only. 

Keep out of the reach AND SIGHT of children. 

Pharmaceutical precautions 

Do not store above 25°C. Store in a dry place.

Keep blister pack in outer carton.

Disposal

Dispose of empty packaging in the household refuse.   Unused product should be returned to the veterinary surgeon for disposal.

Legal category 

POM- V            To be supplied only on veterinary prescription.

Package quantities 

Vivitonin 50 mg tablets   – Packs of 2 x 30 tablets. 

Vivitonin 100 mg tablets – Packs of 6 x 10 tablets. 

Further information 

Nil.

Marketing Authorisation numbers 

Vivitonin 50 mg tablets      Vm 01708/4417

Vivitonin 100 mg tablets    Vm 01708/4446

Marketing Authorisation holder

Intervet UK Ltd.

Walton Manor, Walton

Milton Keynes

Bucks. MK7 7AJ

Licensed distributor in N. Ireland:

Intervet Ireland Ltd.

Magna Drive

Magna Business Park

Citywest Road

Dublin 24

Date of text preparation:

October 2006.

61374^.Nov06/MP